منابع مشابه
Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments.
Chromosome conformation capture approaches have shown that interphase chromatin is partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized topological domains. This compartmentalization is thought to facilitate the matching of genes and regulatory elements, but its precise function and mechanistic basis remain unknown. Cohesin controls chromosome topology to enable DNA repa...
متن کاملPds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.
Pds5 and Wpl1 act as anti-establishment factors preventing sister-chromatid cohesion until counteracted in S-phase by the cohesin acetyl-transferase Eso1. However, Pds5 is also required to maintain sister-chromatid cohesion in G2. Here, we show that Pds5 is essential for cohesin acetylation by Eso1 and ensures the maintenance of cohesion by promoting a stable cohesin interaction with replicated...
متن کاملCohesin loops DNA
Cohesin loops DNA T he glue that holds together sister chromatids also compacts meiotic chromosomes, according to Ding et al. on page 499. This cohesin subunit, called Rec8, seems to tie up chromosomes into loops. The role of Rec8, a meiosis-specifi c cohesin subunit, in chromosome architecture was identifi ed by the authors in a fi ssion yeast screen for meiosis mutants. During meiotic prophas...
متن کاملCohesin loading and sliding.
Cohesin is best known as a crucial component of chromosomal stability. Composed of several essential subunits in budding yeast, cohesin forms a ring-like complex that is thought to embrace sister chromatids, thereby physically linking them until their timely segregation during cell division. The ability of cohesin to bind chromosomes depends on the Scc2-Scc4 complex, which is viewed as a loadin...
متن کاملA cohesin-RAD21 interactome.
The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation. In addition to its canonical function in chromosomal segregation, cohesin has been suggested by several lines of investigation in recent years to play additional roles in apoptosis, DNA-damage response, transcriptional re...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2013
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3663